Science - USA (2020-09-04)
group of patients, in contrast to the subset of individuals tested clinically (fig. S1B), poten- tially because IL-6 was measure ...
Mathewet al.,Science 369 , eabc8511 (2020) 4 September 2020 8of17 RESEARCH | RESEARCH ARTICLE ...
(Fig. 4P). FlowSOM clusters 1 and 6 captured T-bet+memory B cells, whereas FlowSOM clus- ter 5 contained the CD27+CD38+CD138+KI6 ...
Mathewet al.,Science 369 , eabc8511 (2020) 4 September 2020 10 of 17 Fig. 5. Temporal relationships between immune responses and ...
Mathewet al.,Science 369 , eabc8511 (2020) 4 September 2020 11 of 17 RESEARCH | RESEARCH ARTICLE ...
(fig. S6F). Thus, the trajectory of change in the T and B cell response in COVID-19 patients was strongly connected to clinical ...
connections between UMAP components and individual clinical features. UMAP compo- nent 1 correlated with several clinical mea- s ...
CD8 T cells is also a feature of acute Ebola in- fection of macaques and is associated with CD95 expression and severe disease ( ...
antibodies were diluted in FACS buffer with 50% BD Brilliant Buffer (BD, catalog no. 566349). Intracellular mix was diluted in P ...
Batch correction was performed for samples acquired before and after this change to remove potential bias from downstream anal- ...
Populations.PLOS ONE 11 , e0151859 (2016). doi:10.1371/ journal.pone.0151859; pmid: 27008164 A. C. Huanget al., T-cell invigora ...
RESEARCH ARTICLE ◥ CORONAVIRUS Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans Prab ...
and continued to increase up to day 40 after onset of the symptoms (fig. S1). We next used manual gating to identify 25 immune c ...
clinical severity of infection (fig. S1). Addi- tionally, there was reduced expression of pS6 [(phosphorylated ribosomal protein ...
infection (Fig. 3, top row, and fig. S6). These results demonstrate that plasma levels of in- flammatory molecules were signific ...
oncostatin M [(OSM), a regulator of IL-6]. Of note, the TNFSF14 is distinctively enhanced in the plasma of COVID-19–infected ind ...
Arunachalamet al.,Science 369 , 1210–1220 (2020) 4 September 2020 6of11 Top BTMs enriched in DEGs COVID-19 (n=7) vs healthy (n=5 ...
dimensionality reduction through uniform manifold approximation and projection (UMAP) and graph-based clustering. Analysis of ce ...
measured by Olink (Fig. 5E). Finally, we exam- ined whether there is an association between HLA-DR and S100A12 expression in our ...
TNFSF14, EN-RAGE, and OSM (Fig. 3)—coupled with suppressed innate immune responses in blood monocytes and DCs (Fig. 2 and fig. S ...
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