Multiphase Bioreactor Design

The quantitative investigation of substrate uptake requires a time resolution of several few 100 ms, otherwise, artifacts must r ...

Figure 3.2 Schematic representation of stages in a data acquistion system. concomitantly, the window is re-centered around the n ...

BIOREACTOR MODELLING: A PROCESS CONTROL PERSPECTIVE Several closed-loop control strategies are commonly implemented in fermentat ...

the type of bioreactor in study, is obtained by applying general mass, energy and momentum balances (Roels, 1983). In practical ...

classified as structured/unstructured or segregated/non-segregated. Cell models considering the existence of intracellular compo ...

relevant mechanisms in the cell. In the most simple version of such an analysis, all metabolic reactions are lumped together in ...

Figure 3.3 Main sources of knowledge usually available for developing a bioprocess model. model. This knowledge spectrum (Figure ...

develop a process model with the desirable accuracy. In this situation data-driven modelling can be used to improve the accuracy ...

Figure 3.4 Hybrid modular structures: (a) modular complementary structure (b) modular competitive structure. While complementary ...

interconnected modules. Each module is expressed by an input-output relationship based on a particular modelling technique. Seve ...

Figure 3.5 Prediction ability of an hybrid model in a baker’s yeast production process (kinetics module: feedforward network wit ...

layer and 8 units in the hidden layer. Input data: t, V, F, Sinlet.). (a) training data set. (b) validation data set. (c) test d ...

Figure 3.6 Extrapolation measure weighting mechanism: (a) set of P discrete measured points used for training the ANN (in a two- ...

require experiments at lab or pilot scale with extremely well controlled environmental conditions. In the same way a new strain ...

shown that stochastic optimisation techniques may provide results of the same quality as Pontryagin’s maximum technique with muc ...

measurement device (Figure 3.7a) it results in an identity mapping which will lead to the recovery of real process output (RPO). ...

In all these works, reaction rates are estimated from the measurement of state variables (i.e. concentrations). Some authors hav ...

PID control or even on/off control can be used successfully for controlling some environmental quantities in bioreactors. Temper ...

(DMC) strategy is rather simple. In a DMC strategy (Figure 3.9) the non-linear controller may be derived analytically from the p ...

In the work of Loeblein et al. (1999) a method is presented for evaluating the economic performance of the on-line optimisation ...