Multiphase Bioreactor Design

Figure 3.11 An integrated approach for advanced bioprocess monitoring and control. Requirements of real-time communication/need ...

Estler, M.U. (1995) Recursive On-Line Estimation of the Specific Growth Rate from Off-Gas Analysis for the Adaptive Control of F ...

Modak, J.M. (1993) Choice of control variable for optimization of fed-batch fermentation, Chem. Eng. J., 52, pp. 59–69. Montague ...

Simutis, R., Oliveira, R. and Lübbert A. (1996) Hybrid modeling with neural networks and its utilization in bioprocess control. ...

...

CHAPTER FOUR DESIGN AND MODELLING OF IMMOBILISED BIOCATALYTIC REACTORS BRUNO S.FERREIRA^1 , PEDRO FERNANDES1,2 AND JOAQUIM M.S.C ...

Table 4.1 General aspects related to the use of immobilised biocatalysts. General aspects Specific aspects Advantages RETENTION ...

composition EMPIRICISM —need for case specific, multi- parameter optimisation —difficult process modelling and control The bioca ...

(ii) Partitioning effects, related to the chemical nature of the support material, may arise from electrostatic or hydrophobic i ...

These differences in the equilibrium concentrations of charged soluble compounds may be described by the partition coefficient, ...

concentration difference between the surface and the bulk concentration of substrate and product. For instance, the rate of flow ...

where rmax is the maximum reaction rate, βs is the dimensionless substrate surface concentration ( ) and α 0 , α 1 and α 2 are k ...

Competitive product inhibition: Non-competitive product inhibition: Substrate inhibition and competitive product inhibition: Rev ...

for different values of substrate modulus μ for external diffusion. Figure 4.2 Rate of the inhibited biocatalytic reaction, with ...

The rate of flow of substrate, rdif, or the rate of biocatalytic reaction, rkin, may play predominant roles, depending on their ...

Figure 4.4 Roles of the rate of flow of substrate, rdif, and the rate of enzyme reaction, rkin, on the observed reaction rate, r ...

(12) where Keq is the equilibrium constant for reversible Michaelis-Menten kinetics. Substituting (12) and (8) in (11) and consi ...

Figure 4.5 Effectiveness factor ηext against the substrate modulus μ for external diffusion for different values of the dimensio ...

external diffusion with βB=5, αo= 1 1=1 and for α 1 different of α 2. Internal mass transfer effects When a biocatalyst is immob ...

where Ds is the substrate diffusivity; ε is the void fraction in the porous matrix; and τ is a tortuosity factor that takes into ...