Multiphase Bioreactor Design

Figure 5.1 Classification of two-liquid phase biocatalytic processes based on the solubility of both the substrate (S) and produ ...

may be limited to the aqueous phase saturation concentration of the components. This may also be used to limit exposure of the b ...

(b) Solubility of product. Theoretically it is possible to calculate that for systems of up to two substrates and two products, ...

Figure 5.2 Relationship between solvent Log P value and residual activity measured in aqueous-organic solvent reaction mixtures ...

with regard to the activity of the biocatalyst and the chemical stability of the substrate and product molecules. Where the aque ...

equivalent two-liquid phase reactor has been proposed, known as the liquid-impelled loop reactor (van Sonsbeek et al., 1993). Cl ...

and product concentrations in each of the organic and aqueous phases with time. Biocatalyst inhibition terms due to either speci ...

Figure 5.4 Mass transfer-reaction model for a reaction occurring in the aqueous phase and a biocatalyst exhibiting Michaelis-Men ...

beneath the saturation concentration) to predict substrate and product concentration-time profiles in a Lewis cell with biocatal ...

substrate concentration (0.6 mM) and the reaction rate (0.14 μmol min−^1 ml−^1 ) predicted by the aqueous phase bulk reaction mo ...

Figure 5.6 Integrated design strategy for two-liquid phase biocatalytic processes: (a) may need to compromise on solvent selecti ...

to improve phase separation (Schmid et al., 1998a) and may be applicable where the products are sufficiently stable. As an alter ...

little work has been carried out on the subsequent purification of the target solute from the phase in which it is contained. Gi ...

Figure 5.8 Design chart showing the factors which determine the feasible operating window for a two-liquid phase biocatalytic pr ...

and operation above critical pressures or below critical temperatures. The need to ensure the safe operation of two-phase biotra ...

After much initial interest in two-liquid phase biocatalysis it has become clear that there are three primary applications for t ...

conventional organic solvents. They also have the potential to act as “designer solvents” (Freemantle, 1998) as simple structura ...

Arnold, F.H. (1996) Directed evolution: creating biocatalysts for the future. Chemical Engineering Science, 51, 5091–5102. de Bo ...

Mathys, R.C., Schmid, A., Kut, O.M. and Witholt, B. (1998b) Alkanol removal from the apolar phase of a two-liquid phase bioconve ...

Woodley, J.M. and Titchener-Hooker N.J. (1996) The use of windows of operation as a bioprocess design tool. Bioprocess Engineeri ...