Multiphase Bioreactor Design

Production of -glutamyl-cysteine by -glutamyl-cysteine synthetase with
ATP (PEG bound) regeneration kinase

Berke et al., 1988

Synthesis of glucose 6-phosphate by glukokinase with ATP
regeneration by acetatekinase

Ishikawa et al., 1989a,

1989b

(R)-(-)-mandelic acid from benzoyl formate with NADH regeneration
by formate dehydrogenase

Maeda et al., 1990

Production of amino acids, hydroxyacids, alcohols, aldehydes and
lactones with dehydrogenases

van Eikeren et al., 1990

Production of sulcatol with simultaneous NADPH regeneration by
alcohol dehydrogenase

Röthig et al., 1990

Synthesis of mannitol by mannitol dehydrogenase with NADH
regeneration by glucose dehydrogenase in a charged MR

Kulbe et al., 1990

Coenzyme dependent reactions catalysed by dehydrogenases
(production of propyl alcohol, lactate and 6-phosphogluconoate)

Miyawaki et al., 1990;

Obóm et al., 1998

Synthesis of L-alanine by alanine dehydrogenase with NADH
regeneration by lactate dehydrogenase

Fujii et al., 1991

Production of sorbitol by aldose reductase with NADPH regeneration
by glucose dehydrogenase in a charged MR

Ikemi et al., 1990a,

1990b

Production of NADPH with alcohol dehydrogenase in an ultrafiltration
cell

Peters & Kula, 1991

Synthesis of 12-ketoursodeoxycholic acid by dehydrogenases with
NADH and NADPH regeneration

Carrea et al., 1992

Synthesis of organic compounds by methylenehydroxilases with
electrochemical enzyme reactivation using flavocytochromes

Brielbeck et al., 1994

Synthesis of L-tert-Leucine by leucine dehydrogenase with NADH regeneration
by formate dehydrogenase in 2 MR in series

Kragl et al.,

1996b

Production of (S)-l-acetoxy-2-alkanol with NADPH regeneration using bakers’
yeast cell free extract

Ishihara et al.,

1996

Reduction of 2-ketoglutarate to L-glutamate by glutamate dehydrogenase with
NADH regeneration by glucose dehydrogenase in a nonofiltration MR

Lin et al., 1997

Production of L-carnitine by L-carnitine dehydrogenase with NADH regeneration
by glucose dehydrogenase

Lin et al., 1999

Production of xylitol by xylose reductase with NADH regeneration by glucose
dehydrogenase in a charged MR

Nidetzky et al.,

1996b

Production and extraction of (S)-1-phenyl-2-propanol by alcohol dehydrogenase
with NADH regeneration by formate dehydrogenase

Kragl et al.,

1996a

Resolution of l-phenyl-1, 2 ethanediol by glycerol dehydrogenase with NADH
regeneration by lactate dehydrogenase

Liese et al.,

1996

Enantioselective reduction of 2-octanone by carbonyl reductase in an emulsion,
two membrane reactor

Liese et al.,

1998 v

Multiphase bioreactor design 170