SCIENCE sciencemag.org
responses to environmental
antigens. Atopic individuals
have increased susceptibility
to bacterial and viral infections;
however, the contribution of
immune cells such as neutrophils
to this susceptibility is not well
defined. Egholm et al. studied
neutrophil-mediated immunity
to Listeria monocytogenes or
Staphylococcus aureus infection
in mice with genetic or induced
predisposition to type 2 immune
responses. Neutrophil-mediated
responses were impaired in
mice with type 2 predisposition
because of neutrophil intrinsic
interleukin-4 receptor (IL-4R)
signaling. IL-4R signaling acceler-
ated neutrophil aging, resulting
in reduced effector functions,
increased apoptosis, and an
impaired ability to clear bacte-
ria. These findings provide new
insights into the interplay between
type 2 immune predisposition and
neutrophil function. —HMI
Sci. Immunol. 7 , eabi9733 (2022).
APPLIED PHYSICS
Ultra-broadband terahertz
detection
Because of the low energies
involved, terahertz detection has
presented a difficult challenge.
Ratchets, which use local asym-
metries to rectify nondirectional
signals, could be a promising
solution but have mostly been
a theoretical concept to date.
Bai et al. successfully fabricated
and demonstrated a gallium-
arsenide–based ratchet structure
that was able to efficiently detect
radiation in the near-infrared to
terahertz range. The device has
an elusive combination of broad
response (4 to 300 terahertz)
and peak responsivity five orders
of magnitude higher than that of
existing broadband photon-type
detectors. These devices will be
promising for a range of appli-
cations, including biomedical,
astrophysics, security, and com-
munication systems. —SDS
Sci. Adv. 10.1126/
sciadv.abn2031 (2022).
27 MAY 2022 • VOL 376 ISSUE 6596 959-CRESEARCH