iThei mdcdaelcinfd o c elllllrllll mmthsl mbThkThhpsmolecules for various immune processes as well signaling the thymus to
send reinforcements, thus stimulating more of their own production and
suppressing the production of other cytokines (i.e., Th1 cytokines stimu-
late the production of Th1 cytokines and suppress Th2 cytokines, and
vice versa). Under normal conditions, a balance of these types of cells is
maintained; in autoimmune conditions, however, an imbalance occurs.
Figure 6: T Helper Cell Differentiation- Immunosuppression
- Self-tolerance
- Immunity against viruses and bacteria
- Autoimmunity
- Immunity against parasites
- Asthmas and allergic reactions
- Immunity against fungi
- Autoimmunity
Treg
Th 1
Th 2
Th 17
Adapted from Filén S, Lahesmaa R. GIMAP proteins in T-lymphocytes. Journal of Signal
Transduction. 2010.
Th1
Th1 cells are part of the branch of the immune system known as cellular
or cell-mediated immunity. Th1 cells act as our line of defense against
intracellular pathogens, or pathogens that live and replicate inside of our
cells, such as viruses and some types of bacteria.
This type of immune response is most effective at removing virus-infected