iThei mdcdaelcinfd o c elllllrllll mmthsl mbThkThhpswithin a couple of days to a few weeks. Early research suggests anatabine
must be taken continuously to exert its affect on the immune system.
Side effects of headache, nausea, vomiting, and changes in liver function
have been observed when doses were started too high.
I personally tried anatabine in 2012 for three months when I was in the
middle of my root cause search, and it lowered my TPO antibodies by
about 50 percent (I didn’t have any remaining TG antibodies at the time).
What I found particularly interesting is not everyone responds the same
to anatabine. The researchers in the above study note that not all subjects
had a drop in TG antibodies, and some had a greater drop than others
did. Of course, this makes sense as not everyone has the same root cause.
This supplement may be a helpful tool in reducing inflammation and
antibodies while searching for why the immune system is imbalanced.
Note: Some individuals with Hashimoto’s may have a nightshade
sensitivity.
Update: In September 2014, anatabine was pulled from the market in
response to an FDA warning letter. Anatabine was initially considered
a dietary supplement by its manufacturer, Rock Creek Pharmaceuticals,
but the FDA indicated anatabine should be studied as a drug before it
could be marketed. According to the Rock Creek Pharmaceuticals web-
site, “The Company has filed an Investigational New Drug (IND) appli-
cation with the U.S. Food and Drug Administration, which is on clinical
hold pending additional data for the Agency to review.”
Curcumin
Derived from the spice turmeric, curcumin has anti-inflammatory ben-
efits that can be helpful in autoimmune conditions. Curcumin produces
an anti-inflammatory effect by down-regulating Th1 cytokines (TNF-A,
IL-1, IL-2, IL-6, IL-8, and IL-12).
Curcumin has been found to reduce joint inflammation in the Th1
autoimmune condition rheumatoid arthritis. Additionally, it seems to
have therapeutic anti-inflammatory effects in a variety of gastrointestinal
conditions. Curcumin improved Crohn’s disease (Th1), ulcerative colitis
(Th2), and IBS.
Although some researchers suggest that the daily intake of curcumin in
a typical Indian diet may be anti-inflammatory, the amount of curcum-
in present in spices may be insufficient to produce anti-inflammatory