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Table 1: Factors That Inhibit T4 to T3 Conversion^9
Nutrient
Depletions Stress Aging Alcohol Obesity
Chemo-
therapy Cigarettes Diabetes Fasting Soy
Medications Goitrogens Pesticides Radiation Surgery
Kidney
and Liver
Disease
Heavy
Metals
Growth
Hormone
Deficiency
Low
Progester-
one
Iodine
Excess
The National Institutes of Health, a government agency (not funded by
pharmaceutical grants), conducted a clinical trial to see if desiccated thy-
roid therapy is advantageous to T4 alone.^8 The authors of the study con-
cluded, “DTE (Desiccated Thyroid Extract) therapy did not result in a
significant improvement in quality of life; however, DTE caused modest
weight loss and nearly half (48.6 percent) of the study patients expressed
preference for DTE over L-T4 (Levothyroxine). DTE therapy may be
relevant for some hypothyroid patients.”^13
Thyroid hormone therapy should be individualized with the patient in
mind. Some people report feeling better on natural desiccated hormone
and others on compounded medications, while others may feel better
taking Tirosint® or another version of synthetic T4.
Some patients may have ethical objections to using animal-derived NDT
products. Compounded T4/T3 products offer an alternative. These medi-
cations also provide the advantage of being made without fillers such as
lactose or gluten, which are present in some thyroid medications and can
be problematic for thyroid patients (as you will learn in the Gut chapter).