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Table 6: Goitrogen Effects on Thyroid
Causes Agents Action
Millet, soy Flavonoids Impairs thyroperoxidase activity -
Cassava, sweet po-
tato, sorghum
Cyanogenic
glucosides
metabolized to
thiocyanates
Inhibits iodine thyroi-
dal uptake
Babassu coconut,
mandioca Flavonoids
Inhibits thyroperoxi-
dase
Cruciferous veg-
etables: cabbage,
cauliflower, broccoli,
turnips, canola
Glucosinolates thyroidal uptakeImpairs iodine
Seaweed (kelp) Iodine excess thyroidal hormonesInhibits release of
Malnutrition Vitamin A deficiency Increases TSH stimulation
Iron deficiency Iron deficiency
Reduces heme-de-
pendent thyroperoxi-
dase thyroidal activity
Selenium deficiency Selenium deficiency
Accumulates
peroxides and
causes deiodinase
deficiency; impairs
thyroid hormone
synthesis
The goitrogens in soy are still present after cooking. Soy is also a com-
mon allergen. People with underactive thyroid function and Hashimoto’s
should avoid soy completely. On a personal note, I have suffered from a
“soy crash,” feeling drained and exhausted the day after eating soy.