Nature - 2019.08.29

3

nature research | reporting summary

October 2018

Animals and other organisms

Policy information about studies involving animals; ARRIVE guidelines recommended for reporting animal research

Laboratory animals Mus musculus on a C57BL/6N background. Adult (3 to 4 months-old) male mice were used.

Wild animals This study did not involve wild animals

Field-collected samples This study did not involve field-collected samples

Ethics oversight Animal experiments were performed in accordance with the Italian law D. L.vo n_26/2014 and approved by local (O.P.B.A.) and

national (Ministry of Health) committees (376-2015PR).

Note that full information on the approval of the study protocol must also be provided in the manuscript.