http://www.theanalyticalscientist.comMapping metabolites
MALD-MSI maps the spatial distribution of metabolites
within liver tissue. The specific localization of certain
biomolecules highlights histopathological structures,
including the hepatic lobules in green, the connective
tissue in pink, and the portal triad that consists of bile
duct, vein, and artery – all in blue. Credit: Klara ScupakovaTyping tumors
MSI data can be used to investigate intratumor heterogeneity
by segmenting histologically undistinguishable tumor
areas into distinct subpopulations. This image shows the
distribution of two lipid species in a human breast tumor
section analyzed by MSI (tumor in red, healthy tissue in
green). Credit: Frédéric Dewez
References- B Flinders et al., “Cross-species molecular imaging of bile salts and lipids in
liver: identification of molecular structural markers in health and disease”,
Anal Chem, 90, 11835–11846 (2018). DOI: 10.1021/acs.
analchem.8b01378. - F Barré et al., “Fast raster matrix-assisted laser desorption/ionization mass
spectrometry imaging of lipids at high lateral resolution”, Int J Mass
Spectrom, 437, 38–48 (2018). DOI: 10.1016/j.ijms.2018.09.015. - F Barré et al., “Specific lipid and metabolic profiles of R-CHOP-resistant
diffuse large B-cell lymphoma elucidated by matrix-assisted laser desorption
ionization mass spectrometry imaging and in vivo imaging”, Anal Chem,
90, 14198–14206 (2018). DOI: 10.1021/acs.analchem.8b02910.
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