Science - 16.08.2019

Normanet al.,Science 365 , eaax1030 (2019) 16 August 2019 6of14

B

C

D

A

Patient 1

electrodes LTp5-LTp6

Picture Viewing

HFB response (60−160Hz)

Free Recall

Peri-ripple HFB response (60−160Hz)

Time from picture onset (ms) Time from ripple onset (ms)

Patient 8

electrodes LTo5-LTo6

Patient 13

electrodes LO5-LO6

Power (dB)

Time from picture onset (ms) Time from ripple onset (ms)

0 1000 2000

0

2

4

Time from picture onset (ms)

Power (dB)

−500 0 500

0

1

Time from ripple onset (ms)

Power (dB)

−500 0 500

0

1

Power (dB)

0 1000 2000

0

5

10

Power (dB)

0 1000 2000

0

2

4

Power (dB)

−500 0 500

0

1

faces (n = 52 ripples)

places (n = 39 ripples)

faces (top 10 images)

places (bottom 10 images)

faces (n = 18 ripples)

places (n = 38 ripples)

faces (top 10 images)

places (bottom 10 images)

places (top 10 images)

faces (bottom 10 images)

places (n = 45 ripples)

faces (n = 63 ripples)

other visually responsive (n = 129)

intermediate visual (n = 18)

face−selective (n = 38)

place−selective (n = 20)

early visual (V1/V2) (n = 12)

non-visual

Electrodes:

RH LH

V1 (BA 17)

V2 (BA 18)

Intermediate retinotopic areas

Fusiform Gyrus

Anatomical regions:

LH RH

Fig. 4. Visually responsive electrodes and examples of peri-ripple
visual reactivation during recall.(A) Multipatient electrode coverage
showing the location of visually responsive electrodes in relation to early
visual areas (blue), intermediate visual areas (yellow), and the fusiform
gyrus (pink). Face- and place-selective bipolar electrode pairs (bipoles)
are colored red and green, respectively. Each dot represents a single
electrode contact taking part in a bipole. Note the clear tendency of
category-selective electrodes to be localized in high-order visual areas
along the ventral stream. (BtoD) Category-selective peri-ripple HFB
response during recall in three representative category-selective sites. Left:
Anatomical location of each recording site. Center: HFB response time-

locked to the onset of picture presentation (comparing face versus place

images; orange bar represents significant time clusters atP< 0.05). Right:

Peri-ripple HFB response during the verbal report of recall, when patients

freely recalled the same face or place images (orange bar represents

significant time points atP< 0.05, Wilcoxon rank-sum test). Note the

category-selective modulation of HFB power around the simultaneously

recorded hippocampal ripple. As can be seen in these examples, the peri-

ripple cortical response involves either amplitude increase or decrease,

depending on the recalled content and whether it matches the preferred

representational content of the recorded site. Black bars on thexaxis

represent stimulus-on periods; shaded areas represent SEM.

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