Science - 16.08.2019

Normanet al.,Science 365 , eaax1030 (2019) 16 August 2019 7of14

Mean effect size (g)[pref. vs. non-pref.]

E F

EVA/retinotopic

LO ITG

lingual/PHG

fusiform gyrus

entorhinal

−500 0 500

preferred images non-preferred images

Time from ripple onset (ms) Time from ripple onset (ms)

−500 0 500

Free recall

peri-ripple spectrograms

n = 57 n = 57

dB

-0.4

0

0.4

Frequency (Hz)

50

100

150

200

Power (dB)

Free recall

peri-ripple HFB response (60−160Hz)

Preferred images

Non-preferred images

n = 57 bipoles

−500 0 500

−0.2

0

0.2

0.4

LH RH

RH LH

(^0) >0.8
peri-ripple
visual reactivation
fusiform
entorhinal
LO
lingual
ITG
PHG
non-visual site
effect size (Hedges’ g)
D
ABC
Time from picture onset (ms)
Power (dB)
Picture viewing
HFB response (60−160Hz)
Preferred images
Non-preferred images
n = 57 bipoles
0 1000 2000
0
2
4
0
10
20
30
40
50
Sig. electrodes (%)^0
0.5
EVA/retinotopic (n=34)
LO (n=27)ITG (n=36)
lingual/PHG (n=30)
FG (n=50)EC (n=7)
Fig. 5. Peri-ripple reactivation across the visual hierarchy during free
recall.(A) HFB response to preferred (top 10) and nonpreferred (bottom
10) images in face/place selective recording sites during viewing. (B) HFB
activity in the same category-selective electrodes during recall, time-
locked to the onset of simultaneously recorded hippocampal ripples. Note
the selective transient increase in HFB power during recall of preferred
versus nonpreferred images (P< 0.05, cluster-based permutation test;
n= 57 bipoles from 13 patients). (C) Multitaper spectrograms showing that
peri-ripple cortical responses were concentrated in a broad high-frequency
range (50 to 180 Hz). (D) Reactivation effect size (Hedges’g) in visually
responsive electrodes, comparing peri-ripple responses during recall of
“preferred”versus“nonpreferred”images. (EandF) Percentage of
significant electrodes (P< 0.05, Wilcoxon rank-sum test, uncorrected)
and mean effect size in each region of interest. Peri-ripple response
selectivity was strongest in the fusiform gyrus and entorhinal cortex. Note
the clear tendency for increased reactivation effect at more anterior-
medial sites. Error bars and shaded areas represent SEM. In (A) and (B),
horizontal orange bars represent significant time clusters.
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