reSeArcH Article
Extended Data Fig. 5 | Lamin A/C Haploinsufficiency results in an
abnormal distribution of open chromatin in LMNA-mutant iPSC-CMs.
a–f, Representative images and normalized signal intensity of ATAC-see
and DAPI of control and mutant iPSC-CMs. Data were obtained from
different patient lines, including the uncorrected and isogenic lines of
patient III-3 (a, b); the uncorrected and isogenic line of control IV-1
(c, d); and the line of patient III-15 (e, f) f or normalized signal intensity
of ATAC-see and DAPI. Data are mean ± s.e.m. g, Correlation of signal
distribution between ATAC-see and DAPI. n = 42 (WT/WT), n = 28
(WT/cor-WT), n = 33 (del-KO/MUT), n = 32 (ins-WT/WT), n = 25
(WT/MUT) for normalized signal intensity of ATAC-see and DAPI. Data
are mean and minimum to maximum; two-tailed Student’s t-test was used
to calculate P values. The experiments in a, c, and e were repeated three
times independently with similar results.