Science - USA (2020-01-03)

4 3 JANUARY 2020 • VOL 367 ISSUE 6473 sciencemag.org SCIENCE

PHOTO: MICHAEL ROBINSON CHAVEZ/THE WASHINGTON POST VIA GETTY IMAGES

RESEARCH

IN BRIEF

36 From Science and other journals

REVIEW

39 Neuroscience
Memory engrams: Recalling the past
and imagining the future
S. A. Josselyn and S. Tonegawa
REVIEW SUMMARY; FOR FULL TEXT:
DX.DOI.ORG/10.1126/SCIENCE.AAW

RESEARCH ARTICLES

40 Nanoparticles

Oriented attachment induces fivefold twins

by forming and decomposing high-energy

grain boundaries M. Song et al.

45 Multiplex genomics

Massively multiplex chemical transcriptomics

at single-cell resolution S. R. Srivatsan et al.

51 Malaria

A Kelch13-defined endocytosis pathway

mediates artemisinin resistance in malaria

parasites J. Birnbaum et al.

PERSPECTIVE p. 22

REPORTS

59 Topological optics

A single photonic cavity with two

independent physical synthetic dimensions

A. Dutt et al.

64 Topological matter

Absence of evidence for chiral Majorana

modes in quantum anomalous Hall-

superconductor devices M. Kayyalha et al.

68 Superconductivity

Atomic manipulation of the gap in

Bi 2 Sr 2 CaCu 2 O8+x F. M a s s e e et al.

71 Applied physics

Topological mechanics of knots and

tangles V. P. Patil et al.

76 Fluorescent proteins

Electrostatic control of photoisomerization

pathways in proteins M. G. Romei et al.

PERSPECTIVE p. 26

79 Optics

On-chip integrated laser-driven particle

accelerator N. V. Sapra et al.

83 Neuroscience

Dendritic action potentials and computation

in human layer 2/3 cortical neurons

A. Gidon et al.

87 Archaeology

Cooked starchy rhizomes in Africa

170 thousand years ago L. Wadley et al.

91 Plant science

Evolution of carnivorous traps from planar

leaves through simple shifts in gene

expression C. D. Whitewoods et al.

PERSPECTIVE p. 24; PODCAST

96 Evolutionary biology

Protein-coding changes preceded

cis-regulatory gains in a newly evolved

transcription circuit C. S. Britton et al.

100 Tubulin

TTC5 mediates autoregulation of tubulin

via mRNA degradation Z. Lin et al.

PERSPECTIVE p. 29

104 Topological matter

Evidence for dispersing 1D Majorana

channels in an iron-based

superconductor Z. Wang et al.

PERSPECTIVE p. 23

ON THE COVER

Immature trap of the

carnivorous plant

Utricularia gibba (~

μm in width), illustrat-

ing its two-layered

cellular structure. Such

cup-shaped leaves have

evolved multiple times

as a mechanism for trap-

ping animals. Analyzing U. gibba, researchers

used a combination of molecular genetics

and computer modeling to reveal how shifts

in gene expression domains can account for

repeated evolution of cup shapes from spe-

cies with planar leaves. See pages 24 and 91.

Image: Karen Lee and Claire Bushell

SCIENCE (ISSN 0036-8075) is published weekly on Friday, except last week in December, by the American Association for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005. Periodicals mail
postage (publication No. 484460) paid at Washington, DC, and additional mailing offices. Copyright © 2020 by the American Association for the Advancement of Science. The title SCIENCE is a registered trademark of the AAAS. Domestic
individual membership, including subscription (12 months): $165 ($74 allocated to subscription). Domestic institutional subscription (51 issues): $2148; Foreign postage extra: Air assist delivery: $98. First class, airmail, student, and
emeritus rates on request. Canadian rates with GST available upon request, GST #125488122. Publications Mail Agreement Number 1069624. Printed in the U.S.A.
Change of address: Allow 4 weeks, giving old and new addresses and 8-digit account number. Postmaster: Send change of address to AAAS, P.O. Box 96178, Washington, DC 20090–6178. Single-copy sales: $15 each plus shipping and
handling available from backissues.sciencemag.org; bulk rate on request. Authorization to reproduce material for internal or personal use under circumstances not falling within the fair use provisions of the Copyright Act can be obtained
through the Copyright Clearance Center (CCC), http://www.copyright.com. The identification code for Science is 0036-8075. Science is indexed in the Reader’s Guide to Periodical Literature and in several specialized indexes.

CONTENTS

New Products ..............................................

Science Careers .......................................... 111

DEPARTMENTS

5 Editorial

Clarity in 2020 By H. Holden Thorp

114 Working Life

Strange dreams By Desiree Dickerson

26 Electrostatics affect the glow
Chromophore twisting is probed
with unnatural amino acids By C. Hu et al.
REPORT p. 76

27 Cancer in sub-Saharan Africa
Knowledge of cancer in Africa brings needed
diversity to improve health worldwide
By T. R. Rebbeck

29 Gene expression regulated by
RNA stability
The factor responsible for autoregulation
of tubulin RNA stability is identified
By O. Shoshani and D. W. Cleveland
REPORT p. 100

POLICY FORUM

30 Sustainable minerals and metals
for a low-carbon future
Policy coordination is needed for global
supply chains By B. K. Sovacool et al.

LETTERS

34 NextGen Voices:
Making science accessible

30

Published by AAAS