Nature - USA (2020-01-16)

Article Extended Data Fig. 6 | Effects of FACT deletion mutants on DNA binding. a, Full-length (FL) FACT and FACT CTD deletions ...

Extended Data Fig. 7 | Coverage maps from H2A–H2B HDX experiments. a, b, H2A and H2B coverage maps from HDX experiments. Each re ...

Article Extended Data Fig. 8 | Interactions between H3–H4 and the SPT16 middle domain are incompatible with FACT interactions ma ...

Extended Data Fig. 9 | Model-to-map f itting for the class 2 map of the SSRP1 MD. a, The class 1 model of the SSRP1 MD (red ribb ...

Article Extended Data Table 1 | Summary of cryoEM data collection and refinement To obtain the best fit between model and map, w ...

       (^)               !"#$%#&'()+!,- .'!)("$') $/ 0 '()+!,- 1 ")%#& 2 ...

        (^)                     =% 8 $I!" 5 % 9 % 5  ")%#& B 8 '!! 8 ...

432 | Nature | Vol 577 | 16 January 2020 Article Activation of the GLP-1 receptor by a non-peptidic agonist Peishen Zhao1,9, Yi- ...

Nature | Vol 577 | 16 January 2020 | 433 Here we investigate TT-OAD2 (Fig. 1a), a non-peptidic compound reported in the patent l ...

434 | Nature | Vol 577 | 16 January 2020 Article abundant class was resolved to 3.0 Å (Extended Data Fig. 2c–f, Sup- plementary ...

Nature | Vol 577 | 16 January 2020 | 435 relative to the transmembrane core in comparison to peptide-bound complexes, whereas bo ...

436 | Nature | Vol 577 | 16 January 2020 Article structures of all solved class B GPCRs revealed direct interactions of the enga ...

Methods Data reporting No statistical methods were used to predetermine sample size. The experiments were not randomized and inv ...

Article adjustment of the model in coot further real-space refinements were carried out with only Ramachandran and rotamer restr ...

ratio. Ligand-mediated cAMP production was measured 48 h after transfection. In brief, culture media was replaced with assay buf ...

Article (PDB) under accession number 6ORV and Electron Microscopy Data Bank (EMDB) accession EMD-20179. Liang, Y.-L. et al. Dom ...

Extended Data Fig. 1 | Binding, transducer coupling and signalling mediated b y T T- OA D 2. a, Kinetic ligand-binding assay usi ...

Article Extended Data Fig. 2 | Purif ication, cryo-EM data imaging and processing of the TT-OAD2–GLP-1R–Gs complex. a, Represent ...

Extended Data Fig. 3 | The atomic resolution model of the TT-OAD2–GLP-1R– Gαs heterotrimer in the cryo-EM density map. Electron ...

Article Extended Data Fig. 4 | Cryo-EM density supports ligand interactions in the TT-OAD2-binding site. a, Interacting residues ...