Nature - USA (2020-01-16)

3

nature research | reporting summary

October 2018

Mycoplasma contamination Cell lines were not tested for myco contamination

Commonly misidentified lines

(See ICLAC register)

No commonly misidentified cell lines were used

Animals and other organisms

Policy information about studies involving animals; ARRIVE guidelines recommended for reporting animal research

Laboratory animals All data presented used mice on the C57Bl/6N or C57Bl/6J background. When possible littermate controls were used. Most

animals were used in the 1-6 week old range, with a few labeled exceptions.

Wild animals This study did not involve the use of wild animals

Field-collected samples This study did not involve the use of wild animals

Ethics oversight Harvard Medical School IACUC

Note that full information on the approval of the study protocol must also be provided in the manuscript.