Article
Extended Data Fig. 8 | Molecular diversity of microglia in the human
hippocampus. a, Heat map showing the expression levels and identities of
genes in the microglia subclasses. The graph above shows the distribution of
each subclass by gestational week. b, Visualization of ten subtypes of microglia
in the developing human hippocampus using t-SNE. Each dot represents a
single cell, and cells are laid out to show similarities. Each cell colour represents
the cell type. Expression of known markers is shown using the same layout on
the right; grey, no expression; red, relative expression. Microglia: 638, 489,
246, 259, 465, 229, 84, 84, 68, 54 and 44 cells. c, d, Distribution of G1, S, and
G2/M stages of the cell cycle for microglia of different subtypes (c) and at
different gestational weeks (d). e, Immunostaining images of PTPRC and MKI67
at GW25. Scale bars, 500 μm (left), 100 μm (right). The experiment was
repeated three times independently with similar results.