Article
Extended Data Fig. 1 | Persistence and development of maternal antibodies.
The genotypes of mating pairs are indicated under the large mouse cartoons;
the small mouse cartoons represent neonates born to the indicated dams and
their genotypes. Red symbols denote the presence in neonates of antibodies
that either were acquired transplacentally from μMT+/− mothers or, in the
case of μMT+/− pups, were generated endogenously after 4 weeks of age.
a, Reciprocal breeding scheme to study maternal antibody persistence and
development. b, Serum IgG concentration in 1–8-week-old pups. Data are
shown as μg ml−1. n = 5–15 mice in each breeding group for every week of
1–8 weeks. Further details are provided in the Source Data. c, IgA
concentrations in small-intestine (SI) and colon (CO) homogenates from
1-week-old pups. Data are shown as μg per small intestine or colon. d, Faecal IgA
concentration in 2–8-week-old pups. Data are shown as μg per g of faeces.
n = 6–13 mice in each breeding group for every week of 2–8 weeks. Further
details are provided in the Source Data. e, Serum IgM concentration in 1-week-
old pups. Data are shown as μg ml−1. f, IgG concentration in small-intestine and
colon homogenates from 1-week-old pups. Data are shown as μg per small
intestine or colon. g, Faecal IgG concentration in 2–8-week-old pups. Data are
shown as μg per g of faeces. n = 5–9 mice in each breeding group for every week
of 2–8 weeks. Further details are provided in the Source Data. b–g, Data are
mean ± s.e.m. Specific n numbers are shown in the figure.