Nature | Vol 577 | 23 January 2020 | 581
- Natsume, T., Kiyomitsu, T., Saga, Y. & Kanemaki, M. T. Rapid protein depletion in human
cells by auxin-inducible degron tagging with sShort homology donors. Cell Reports 15 ,
210–218 (2016). - Ohta, S., Tatsumi, Y., Fujita, M., Tsurimoto, T. & Obuse, C. The ORC1 cycle in human cells:
II. Dynamic changes in the human ORC complex during the cell cycle. J. Biol. Chem. 278 ,
41535–41540 (2003). - Schotta, G. et al. A chromatin-wide transition to H4K20 monomethylation impairs
genome integrity and programmed DNA rearrangements in the mouse. Genes Dev. 22 ,
2048–2061 (2008). - Jørgensen, S., Schotta, G. & Sørensen, C. S. Histone H4 lysine 20 methylation: key player
in epigenetic regulation of genomic integrity. Nucleic Acids Res. 41 , 2797–2806 (2013). - Fan, J. Y., Rangasamy, D., Luger, K. & Tremethick, D. J. H2A.Z alters the nucleosome
surface to promote HP1α-mediated chromatin fiber folding. Mol. Cell 16 , 655–661 (2004). - Wang, Y. et al. Histone variants H2A.Z and H3.3 coordinately regulate PRC2-dependent
H3K27me3 deposition and gene expression regulation in mES cells. BMC Biol. 16 , 107 (2018). - Wu, H. et al. Crystal structures of the human histone H4K20 methyltransferases
SUV420H1 and SUV420H2. FEBS Lett. 587 , 3859–3868 (2013). - Suto, R. K., Clarkson, M. J., Tremethick, D. J. & Luger, K. Crystal structure of a nucleosome
core particle containing the variant histone H2A.Z. Nat. Struct. Biol. 7 , 1121–1124 (2000). - Tatsumi, Y., Ohta, S., Kimura, H., Tsurimoto, T. & Obuse, C. The ORC1 cycle in human cells: I.
Cell cycle-regulated oscillation of human ORC1. J. Biol. Chem. 278 , 41528–41534 (2003).
18. Cayrou, C., Grégoire, D., Coulombe, P., Danis, E. & Méchali, M. Genome-scale
identification of active DNA replication origins. Methods 57 , 158–164 (2012).
19. Bartholdy, B., Mukhopadhyay, R., Lajugie, J., Aladjem, M. I. & Bouhassira, E. E.
Allele-specific analysis of DNA replication origins in mammalian cells. Nat. Commun. 6 ,
7051 (2015).
20. Tubbs, A. et al. Dual roles of poly(dA:dT) tracts in replication initiation and fork collapse.
Cell 1 74, 1127–1142 (2018).
21. Dellino, G. I. et al. Genome-wide mapping of human DNA-replication origins: levels of
transcription at ORC1 sites regulate origin selection and replication timing. Genome Res.
23 , 1–11 (2013).
22. Alabert, C. et al. Two distinct modes for propagation of histone PTMs across the cell
cycle. Genes Dev. 29 , 585–590 (2015).
23. Sima, J. et al. Identifying cis elements for spatiotemporal control of mammalian DNA
replication. Cell 176 , 816–830 (2019).
24. Eaton, M. L., Galani, K., Kang, S., Bell, S. P. & MacAlpine, D. M. Conserved nucleosome
positioning defines replication origins. Genes Dev. 24 , 748–753 (2010).
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