Extended Data Table 3 | Concentrations of free haematin [H], free inhibitors [D] and kink blocker–haematin complexes [H 2 B]
Concentrations modified by inhibitor–haematin complexation were evaluated at analytical concentrations of haematin cH and inhibitor CB using complexation constants 14 and 510 mM−2 for MQ
and AQ, respectively^13. Evaluation of v′ 0 lowered from the step velocity in the absence of inhibitors v 0 owing to the decrease of haematin concentration from cH to [H]. The variables v′( 00 vv′−)−1
and cB−1 of the linearized form of the correlation between v and cD, Supplementary equation (7), for cB = [B] and cB = [H 2 B], respectively.