Nature | Vol 578 | 13 February 2020 | E19Corrections & amendments
Author Correction:
Structural basis for the
drug extrusion
mechanism by a MATE
multidrug transporter
https://doi.org/10.1038/s41586-019-1762-6
Correction to: Nature https://doi.org/10.1038/nature12014
Published online 27 March 2013
Yoshiki Tanaka, Christopher J. Hipolito, Andrés D. Maturana,
Koichi Ito, Teruo Kuroda, Takashi Higuchi, Takayuki Katoh,
Hideaki E. Kato, Motoyuki Hattori, Kaoru Kumazaki,
Tomoya Tsukazaki, Ryuichiro Ishitani, Hiroaki Suga & Osamu Nureki
In this Article, three of the images in Fig. 2b are incorrect. In the growth
complementation tests of ΔacrB strains, all 14 lower panels, from (−)
for +Norflaxin to M206A for +Norfloxacin, should have been cropped
from the original plate images. However, during the preparation of Fig.
2b we inadvertently cropped the lower panels for Y139A, N157A and
N180A from the wrong plates (P26A, M206A and M173A, respectively).
Figure 1 shows the incorrect, as-published original Fig. 2b and the cor-
rected Fig. 2b, with the three affected lower panels (Y139A, N157A and
N180A for +Norflaxin) now corrected. Since all the growth scores for
both the corrected and the incorrect, as-published panels are negative
(that is, marked ‘−’ for not complemented), these errors do not change
our conclusion for the evaluation of the mutation effects. The original
Article has not been corrected online.
+ Nor oxacin
0.02 μg ml–1- Nor oxacin
ΔacrB
(–) (–) WT D41A D41ND184A D184NY139AN180AP26A N157AM173A S177L M206A+ Nor oxacin
0.02 μg ml–1- Nor oxacin
2b 2bIncorrect Corrected
acrB+ acrB+ ΔacrBPfMATE++++++ + ++++ ++++ +++++–––––––++++ –– –––––– –– ––– ––––++++++ + ++++ ++++ +++++–––––––++++ –– –––––– –– ––– ––––++++ +++++ ++ ++- – –– –– ––– – ––
++++ +++++ ++ ++- – –– –– ––– – ––
(–)W(–) TDD41A 41ND184A D184NY139AN180AP26A N157AM173A S177LPM206A fMATEFig. 1 | This f igure shows the incorrect, as-published original Fig. 2b and the corrected Fig. 2b.