Science - USA (2020-02-07)

REVIEW SUMMARY ◥ MEDICINE The biology, function, and biomedical applications of exosomes Raghu Kalluri*and Valerie S. LeBleu BAC ...

REVIEW ◥ MEDICINE The biology, function, and biomedical applications of exosomes Raghu Kalluri1,2,3*and Valerie S. LeBleu^1 The ...

cancerous breast epithelial cells. The breast cancer cells shed lower numbers of exosomes (~60 to 65 per cell per hour) compared ...

expression promote exosome uptake by macro- pinocytosis in human pancreatic cancer cells ( 27 , 28 ). Human melanoma cells uptak ...

enriched in many proinvasive molecules ( 39 ). Neural stem cells challenged with inflamma- tory cytokines produce exosomes with ...

mice, tumor eradication and growth delay were observed with a single intradermal injection of APC-derived exosomeswithMHC-IIload ...

Kalluriet al.,Science 367 , eaau6977 (2020) 7 February 2020 6of15 Fig. 5. Regulation of immune response by exosomes.Exosomes fro ...

of macrophages ( 81 ), possibly generating an immunosuppressive microenvironment. Modulation of immune responses by exo- somes m ...

and rats despite limited knowledge on how exosomes potentiate these effects. Exosomal microRNAs, including miR-19a, miR-21 [from ...

been reported in multiple cancer types. For example, TGFb(transforming growth factor-b) expressed on the surface of cancer cell– ...

their usefulness in early diagnosis ( 193 ). This may be in part driven by the genomic land- scape of cancer cells, with oncogen ...

cells and epithelial cells do not induce toxicity when repeatedly injected in mice ( 35 , 57 ). MSC- derived exosomes have been ...

G. van Niel, G. D’Angelo, G. Raposo, Shedding light on the cell biology of extracellular vesicles.Nat. Rev. Mol. Cell Biol. 19 ...

S. Ahmadi Badiet al., Microbiota-derived extracellular vesicles as new systemic regulators.Front. Microbiol. 8 , 1610 (2017). d ...

mature neurofibrillary tangles in ALZ17 mice.J. Alzheimers Dis. 54 ,1207–1217 (2016). doi:10.3233/JAD-160371; pmid: 27567840 L. ...

D. J. Chaet al., KRAS-dependent sorting of miRNA to exosomes.eLife 4 , e07197 (2015). doi:10.7554/eLife.07197; pmid: 26132860 A ...

RESEARCH ARTICLE SUMMARY ◥ PLANT SCIENCE Enhanced sustainable green revolution yield via nitrogen-responsive chromatin modulatio ...

RESEARCH ARTICLE ◥ PLANT SCIENCE Enhanced sustainable green revolution yield via nitrogen-responsive chromatin modulation in ric ...

(versus theRht-B1acontrol allele; Fig. 1B and fig. S1, D to F). In contrast, either exog- enous gibberellin treatment or overexp ...

supply progressively increased H3K27me3 modification of bothD14andOsSPL14in wild- type plants, and these effects were also abol- ...