Science - USA (2020-03-13)

RESEARCH ARTICLE SUMMARY ◥ NEUROSCIENCE Cerebrospinal fluid influx drives acute ischemic tissue swelling Humberto Mestre*, Ting ...

RESEARCH ARTICLE ◥ NEUROSCIENCE Cerebrospinal fluid influx drives acute ischemic tissue swelling Humberto Mestre1,2, Ting Du1,3, ...

was the primary source of edema fluid, we performed CSF cisternography using three- dimensional (3D) fast imaging employing stea ...

SDs trigger CSF flow into the ischemic brain MRI suggested that the volume of CSF rapid- ly declined upon artery occlusion, so w ...

peak of GCaMP coverage revealed that the SD preceded a 5.6-fold increase in the area covered by CSF tracer (Fig. 3C). The SD pea ...

( 35 , 37 ). Constriction of both the penetrating and pial arterioles was followed by a parallel increase in the space occupied ...

we acquired 2P imaging after intracisternal in- fusion of a small CSF tracer (3-kDa dextran; Fig. 6E). During SI, tracer entered ...

infarction (fig. S9 and table S1). Edema was primarily seen in brain regions that are known flow pathways for CSF-ISF rather tha ...

the predominant vasomotor response after SD across a variety of diseases and animal models [i.e., mice ( 35 ), rats ( 62 ), cats ...

A score of 3 was given to mice who would immediately fall from the string when released, a 2 if the mouse was able to hang on th ...

Mestreet al.,Science 367 , eaax7171 (2020) 13 March 2020 10 of 15 N CSF tracer AQP4 -15 -10 -5 0 5 10 15 0 5 10 Time after MCAO ...

thickness = 0.3 mm) 30 s immediately after macrosphere infusion: If angiography did not show occlusion of MCA, the animal was ex ...

15 min and then 4% paraformaldehyde (PFA) for an additional 30 min. The coronal sections were then imaged under the microscope f ...

(version 3.6.0,www.itksnap.org), ImageJ (version 2.00, NIH, Bethesda, MD, USA), and Matlab (version 9.3.0, MathWorks, Natick, MA ...

whereVi( 1 )arethefinalPVSvolumes.The wave covering pial surface vessels (i,j)∈E triggers an analogous dilation response d dt Ci ...

J. P. Dreieret al., Nitric oxide scavenging by hemoglobin or nitric oxide synthase inhibition byN-nitro-L-arginine induces cort ...

RESEARCH ARTICLE SUMMARY ◥ COMETARY SCIENCE Ammonium salts are a reservoir of nitrogen on a cometary nucleus and possibly on som ...

RESEARCH ARTICLE ◥ COMETARY SCIENCE Ammonium salts are a reservoir of nitrogen on a cometary nucleus and possibly on some astero ...

and/or differing properties of the salts present on the cometary surface (such as concentra- tion, mixing, and counter-ions). We ...

3.2-mm feature. The counter-ion (in this case, the anion) is not fully constrained. The iden- tification of HCOOH by the Rosetta ...