Science - USA (2020-03-13)

of the quaternizingN-benzyl group. Encourag- ingly,L·1c(4-CF 3 C 6 H 4 ) gave increased enantio- selectivity (39% ee) andL·1d(3, ...

Genovet al.,Science 367 , 1246–1251 (2020) 13 March 2020 3of6 Fig. 2. Enantioselective desymmetrizing C–H borylation of benzhydr ...

end of the reaction. Evaluating ee of3a′at various levels of conversion as well as sub- mitting racemic3a′to the enantioselectiv ...

further investigations and optimization are likely required to enable this to be a general procedure (fig. S6). At this stage, w ...

Suzuki-Miyaura coupling on3bin the presence of one equivalent of tetrabutylammonium hydroxide, we were able to achieve >20:1 ...

WATER RESOURCES Colorado River flow dwindles as warming-driven loss of reflective snow energizes evaporation P. C. D. Milly*and ...

(Fig. 2 and Fig. 3, A and B) as well as discharge (Fig. 3G) to constrain a hydrologic simulation model ( 15 ), which we used to ...

tends to evaporate), runoff is suppressed during warm years. To remove the confounding varia- bles from our comparison of the de ...

series, whereas the modeled climate time series were biased and independent of actual history.) From CMIP5’s historical, Represe ...

IMMUNOLOGY mRNA destabilization by BTG1 and BTG2 maintains T cell quiescence Soo Seok Hwang^1 , Jaechul Lim^1 , Zhibin Yu1,2,3, ...

their specific role in the immune system (Fig. 1B). The same pattern was observed in mouse tissues(fig.S1B).Next,weconfirmedthat ...

mice using CRISPR-Cas9 technology ( 16 ). We confirmed correct insertions of two loxP sites in bothBtg1/2and checked their effic ...

pathogenic T cell responses in vivo (fig. S8). BTG1/2 appear to play an indispensable role in limiting spontaneous activation of ...

are no longer expressed, showed no difference in mRNA degradation between WT and DKO (fig. S15), suggesting that BTG1/2 contribu ...

CORONAVIRUS Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation Daniel Wrapp^1 , Nianshuang Wang^1 , Kizzmeki ...

Wrappet al.,Science 367 , 1260–1263 (2020) 13 March 2020 2of4 Fig. 2. Structural comparison between 2019-nCoV S and SARS-CoV S. ...

After collecting and processing 3207 micro- graph movies, we obtained a 3.5-Å-resolution three-dimensional (3D) reconstruction o ...

cell receptor, angiotensin-converting enzyme 2 (ACE2) ( 22 , 25 – 27 ), prompted us to quantify thekineticsofthisinteractionbysu ...

CANCER Rare driver mutations in head and neck squamous cell carcinomas converge on NOTCH signaling Sampath K. Loganathan^1 , Kri ...

prone to developing HNSCC than cSCC com- pared with mice withp53orTgfbrIIloss (fig. S4, A to E). Sequencing of the sgRNA target ...