Nature 2020 01 30 Part.02

(Grace) #1

Extended Data Fig. 6 | Mapping previously isolated mutations in Spt3 and
T B P. Several classes of Spt3 and TBP mutations were shown to interact
genetically with respect to transcription. Mutations from two major studies^21 ,^64


are mapped on the structure of Spt3 and TBP in the SAGA–TBP complex. The
mutations appear to cluster at the contact sites between TBP and Spt3.
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