COMINGSOON
Resolving Cell Subtype Specialization with scRNA-seq
and RNAscopeWEBINAR SPONSORED BYStudying layers of cells grown on flat surfaces leaves a lot to be desired, as cellular responses and gene expression change when cells are not in their native,
3-D arrangements. Researchers develop organoids from primary cell lines or stem cells, and these structures are similar in architecture to primary tissue,
which makes them relevant models of in vivo conditions. Scientists use organoids to study many areas of human biology, including toxicology, infection, and
cancer. Join our panel in this webinar, brought to you by The Scientist and sponsored by Bio-Techne, to hear how researchers use human cerebral and tumor-
derived organoids to better mimic the state of living tissue for drug development and infection studies.Discover how a combination of single-cell RNA sequencing (scRNA-seq) and quantitative RNA in situ hybridization (RNAscope) resolves molecular
specialization of cell subtypes. Using scRNA-seq and RNAscope, a team from Stanford University defined the molecular and anatomical diversity of
adult murine striatum spiny projection neurons (SPNs). In this webinar, sponsored by ACD, Ozgun Gokce will describe how the team generated a cell
type atlas of the adult murine striatum by developing a novel computational pipeline that distinguishes discrete versus continuous cell identities in
scRNA-seq data. He will discuss how SPNs in the striatum can be classified into four discrete types that reside in distinct anatomical clusters or are
spatially intermingled. Jyoti Phatak from ACD will highlight the cell subtype resolving power of scRNA-seq and RNAscope.CATHRYN HAIGH, PhD
Chief, Prion Cell Biology Unit
Laboratory of Persistent Viral Diseases
National Institute of Allergy
and Infectious Diseases
Division of Intramural Research
Rocky Mountain Laboratories
National Institutes of HealthOZGUN GOKCE, PhD
Group Leader, Institute for Stroke and Dementia
Research (ISD)
LMU MunichDANIELA S. GERHARD, PhD
Director, the Human Cancer Model Initiative
Director, Office of Cancer Genomics
National Cancer Institute
National Institutes of HealthJYOTI PHATAK
Associate Scientist
Advanced Cell Diagnostics, a Bio-Techne BrandTUESDAY, APRIL 14, 2020
2:30 - 4:00 PM ESTREGISTER NOW!
http://www.the-scientist.com/organoids-human-healthREGISTER NOW!
http://www.the-scientist.com/rnascope-acdTOPICS TO BE COVERED- Human cerebral organoid applications for prion
disease - Insights from the Human Cancer Models Initiative
TOPICS TO BE COVERED- Validation and selection of RNA in situ targets
- The differences between discrete and continuous
cell identities and how to distinguish them in scRNA-
seq data
Using 3-D Organoids to Answer Questions
About Human Health
COMINGSOONTHURSDAY, APRIL 30, 2020
2:30 - 4:00 PM ESTWEBINAR SPONSORED BY