Science 14Feb2020

RESEARCH ARTICLE SUMMARY ◥ DEVELOPMENTAL BIOLOGY Lineage tracing on transcriptional landscapes links state to fate during differ ...

RESEARCH ARTICLE ◥ DEVELOPMENTAL BIOLOGY Lineage tracing on transcriptional landscapes links state to fate during differentiatio ...

culture. After 2 days, 40% were profiled by scSeq, with the remainder transplanted into 10 sublethally irradiated host mice ( 10 ...

single-cell state maps and their underlying clonal relationships. Clonal dynamics identify early transcriptional fate boundaries ...

by discrete, stepwise transitions in state and fate potential. We interrogated the gene expression heter- ogeneity defining this ...

been characterized in hematopoiesis [n=447 (391 unique) differentially expressed genes at false discovery rate (FDR) = 0.05; tab ...

this expectation. For each of three fate choices [Neu versus Mo, Neu/Mo versus Er/Mk/Ma/ Ba, and Ly/DC versus all myeloid] and a ...

Weinrebet al.,Science 367 , eaaw3381 (2020) 14 February 2020 7of9 Differentiation “pseudotime” start (MPP) end (Neu) Pseudotime, ...

distinct clonal relationships and gene expres- sion dynamics. These results are consistent with a recent findingthatimmunophenot ...

suggest a set of experimental parameters— operant in our in vitro experiment—that may be favorable for inferring clonal relation ...

RESEARCH ARTICLE SUMMARY ◥ NEUROSCIENCE Resilience after trauma: The role of memory suppression Alison Mary, Jacques Dayan, Giov ...

RESEARCH ARTICLE ◥ NEUROSCIENCE Resilience after trauma: The role of memory suppression Alison Mary^1 , Jacques Dayan1,2, Giovan ...

reduction of priming effect after memory sup- pression was not found in the PTSD group [t 54 =−0.84,P= 0.4], and the magnitude o ...

activity during retrieval suppression when mem- ories involuntarily intrude into consciousness compared with when they do not ( ...

quantitatively comparable to TNT-dependent connectivity estimates (see materials and meth- ods). Using these estimates of restin ...

of intrusion. Focusing this analysis on the right anterior MFG revealed that the con- nectivity with memory sites, including the ...

the necessary coping resources that maintain a healthy memory. In trauma-exposed individuals without PTSD, the functional connec ...

might therefore be crucial to cope with trau- matic events. The disruption of memory control mecha- nisms seen in PTSD might als ...

paving the way for new treatments unrelated to the trauma and promoting resilience ( 54 ). Materials and methods Participants Ei ...

incidentally avoided ethical issues for the trauma-exposed group. Procedure Before MRI acquisition, participants learned 72 Fren ...