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The human microbiome comprises trillions of commensal microbes. These bacteria, fungi, and viruses, which naturally reside within the human body, have
been documented to a
ect epigenetic mechanisms, metabolic activity, and immune system function. Researchers are now focusing on how microbiome
perturbations impact human health and disease. In particular, certain gut microbiota profi les have been linked to the development of neurological
disorders, including autism spectrum disorder, schizophrenia, stress, and depression. For a more detailed look at how our resident microbes impact our
brains, as well as how microbiome manipulation may open therapeutic avenues for these disorders, The Scientist is bringing together a panel of experts who
will share their research, summarize the state of the science, and discuss the next steps for those looking to adopt the technique.

JANE FOSTER, PhD

Associate Professor

Department of Psychiatry &

Behavioral Neurosciences

McMaster University

The Brain-Microbiome Axis: Links Between
Neurological Disease and Microbiota
COMINGSOON

WEDNESDAY, SEPTEMBER 26

2:30–4:00 PM, EASTERN TIME

REGISTER NOW!

http://www.the-scientist.com/BrainMicrobiomeAxis

The webinar video will also be available at this link.

HELEN TREMLETT, PhD

Professor, Canada Research Chair in

Neuroepidemiology & Multiple Sclerosis

Mowafaghian Centre for Brain Health

Faculty of Medicine (Neurology)

University of British Columbia Hospital

TOPICS TO BE COVERED:

• How resident microbiota can influence the
  neurological health of their host


• Whether microbiome manipulations can alter the
  course of human neurological disease

ONDEMAND

Researchers have long known that cellular senescence, telomere shortening, and changes in gene expression contribute to aging. Recently, scientists
have discovered that epigenetic changes, such as the presence of methyl groups in close proximity to CpG dinucleotides located near a gene’s promoter,
also correlate with age. Technological advances, including microarray analysis and next–generation sequencing, have clarifi ed the relationship between
DNA methylation and aging, to the point that such epigenetic modifi cations may even be used to predict one’s chronological age. For a detailed look at
the biology of human aging and the dynamics of DNA methylation, The Scientist invites you to listen in on a discussion with geneticist Steve Horvath, who
discusses the epigenetic clock of cellular aging and how it can be modifi ed by biology and behavior.

STEVE HORVATH, PhD, ScD

Professor, Department of Human Genetics

and Biostatistics

University of California, Los Angeles

DNA Methylation:

Timekeeper of Biological Age

WATCH NOW!

http://www.the-scientist.com/EpiAge

TOPICS TO BE COVERED:

• The role of persistent and ephemeral epigenetic
  marks in setting and resetting cellular age


• Targeting the disease of aging with pharmaceuticals

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