Article
Competing interests Z.L. and M.V.B. have patent applications on epigenetic therapy. J.R.B.,
C.M.R., P.M.F. and R.A.J. serve on the advisory boards of Bristol-Meyers Squibb (BMS) and
AstraZeneca. J.R.B., P.M.F. and R.A.J. are on the advisory board of Merck and receive grant
support from BMS. J.R.B., C.M.R. and R.A.J. are on the advisory boards of Amgen and
Genentech/Roche. Y.J.K., P.M.F. and R.A.J. serve on the advisory board of Novartis. C.M.R. and
J.R.B. are on the advisory board of Celgene. J.R.B. and P.M.F. serve on the advisory boards of Eli
Lilly and Jansen. C.M.R. and P.M.F. are on the advisory board of AbbVie. R.A.J. and P.M.F. serve
on the advisory board of Boehringer Ingelheim. R.A.J. and Y.L.K. are on the advisory board of
Takeda. R.A.J. is on the advisory board of Pfizer. S.R.B. is a consultant to BMS. J.W. is cofounder
and chief medical officer of Precision Genetics. J.R.B. serves on the advisory board of Syndax,
and receives honoraria from Roche/Genentech. C.M.R. is a consultant to and/or advisory board
member for Ascentage, Daiichi Sankyo, Ipsen, Loxo, Pharmamar, Vavotek, Bridge Medicines
and Harpoon Therapeutics. Y.J.K. serves on the advisory boards of Dracen, Aduro and Sanofi.
P.M.F. is a consultant to and/or advisory board member for EMD Serono and lnivata, and
receives grant support from Corvus, Kyowa and Novartis. S.B.B. serves on the advisory boards
of Mirati Therapeutics, MDxHealth and Aminex Therapeutics. M.V.B., Y.M., J.R.B., P.M.F. and
R.A.J. receive grant support from AstraZeneca. R.A.J. and J.R.B. receive grant support from
Merck. All other authors declare no competing interests.Additional information
Supplementary information is available for this paper at https://doi.org/10.1038/s41586-020-
2054-x.
Correspondence and requests for materials should be addressed to F.H., S.B.B., L.S. or M.V.B.
Peer review information Nature thanks Michele De Palma, Maria Figueroa and the other,
anonymous, reviewer(s) for their contribution to the peer review of this work.
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