Article
Extended Data Fig. 10 | Representation of the effect of low-dose adjuvant
epigenetic modif iers on lung metastases in the tumour pulmonary-
metastasis models. Graphic model showing the inhibition of pulmonary
metastases by low-dose AET via its effect on MDSCs. First, low-dose AET can
inhibit the trafficking of monocytic and polymorphonuclear MDSCs from the
bone marrow to the premetastatic microenvironment by downregulating the
expression of CCR2 and CXCR2, respectively. Second, even if MDSCs migrate
to the lung, low-dose AET can skew the differentiation of monocytic MDSCs
towards an interstitial macrophage-like phenotype in the lung premetastatic
microenvironment. Therefore, low-dose AET can disrupt the lung
premetastatic microenvironment, ultimately inhibiting pulmonary
metastases.