Science_-_7_February_2020_UserUpload.Net

704 7 FEBRUARY 2020 • VOL 367 ISSUE 6478 sciencemag.org/custom-publishing SCIENCE

new products: cell/tissue culture

LIFE SCIENCE TECHNOLOGIES Produced by the Science/AAAS Custom Publishing Office

Perfusion-Based Dendritic Cell

Culture Platform

The Corning MicroDEN automated

perfusion system enables the efficient

generation of dendritic cells from

monocytes. It delivers reproducible

results in less time while reducing

contamination risk, as compared to

the current “Gold Standard” manual

approach to manufacturing dendritic

cells. The system is programmed

to perform the generation, washing, and harvesting steps with

Corning single-use, closed-system technology. The technician

loads peripheral blood mononuclear cells (PBMCs) or enriched

monocytes with the preferred differentiation media, and places the

MicroDEN system into the incubator.

Corning

F o r i n f o: 8 0 0 - 492-1110

http://www.corning.com/lifesciences

Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this

space. Emphasis is given to purpose, chief characteristics, and availability of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not

implied. Additional information may be obtained from the manufacturer or supplier.

Electronically submit your new product description or product literature information! Go to http://www.sciencemag.org/about/new-products-section for more information.

Cell Line for Recombinant Antibody Production

ProteoGenix decided to overcome the cost and timeline issues

associated with the production of monoclonal antibodies for

preclinical trials. Our solution? XtenCHO, a high-performance cell

line combining high-productivity yields with inexpensive reagents.

As proven in our comparative study, this new Chinese hamster ovary

(CHO) transient gene expression system outperforms most of the

solutions currently available. For pembrolizumab, utolimumab, and

claudiximab production, XtenCHO’s production yields are 1.2–1.9

times higher than ExpiCHO and 3.0–8.5 times higher than CHO-S

(with each system measured in their optimal conditions). In ideal

conditions, XtenCHO achieves a maximum yield of 1.28 g/L for

claudiximab. Its high efficiency was also validated for chimeric

(0.5 g/L) and bispecific antibodies (CrossMab, DuoBody, and Fab-Fab;

yields around 200 mg/L). At ProteoGenix we strive for the success

of every antibody production project. XtenCHO is our solution for

decreasing the production costs of therapeutic antibodies and

accelerating your way to the clinic.

ProteoGenix

For info: +33-(0)-390-20-54-70

http://www.proteogenix.science

Incubation Monitoring System

The OLYMPUS Provi CM20 monitoring system provides quantitative

data about the health of cell cultures while they are in the incubator.

The system periodically scans the cultures, counts the number of

cells without the need of staining or peeling, determines confluency,

and wirelessly communicates the data to a tablet or PC. It has a

thin, compact design, and can be installed in confined spaces.

Using the CM20 system, you can acquire data that will improve the

reproducibility and stability of your cell culture process. Cultivating

cell cultures can be costly, complicated, and time consuming, since it

involves multiple steps and careful timing; the CM20 improves quality

management and reduces the amount of labor involved. With proven

experience in regenerative medicine and expertise in optics, image

analysis, and data management, Olympus is uniquely positioned to

empower users to push the boundaries of regenerative medicine.

Olympus

For info: 609-820-5176

http://www.olympus-lifescience.com/en/cell_culture_solution/cm20

18-Well Slides

With its thin ibidi Polymer Coverslip Bottom, the μ-Slide 18 Well

allows for excellent cell adhesion onto the tissue culture–treated

surface. In addition, it has the highest optical quality and is ideally

suited for a variety of microscopic techniques, such as widefield

fluorescence, confocal microscopy, and differential interference

contrast. For scientists who perform special microscopic

applications, such as total internal reflection fluorescence and

superresolution microscopy, ibidi provides the μ-Slide 18 Well

Glass Bottom with a #1.5H D 263 M Schott glass. It is also available

as a sticky-Slide 18 Well without any bottom, which enables the

researcher to mount any chosen substrate. The entire μ-Slide 18

Well family is ideal for experiments with small cell numbers and

low reagent volumes. The spaces between the individual well walls

minimize any well-to-well crosstalk and contamination. Scientists

who would like to test one of the μ-Slide 18 Well variations with their

own experiments can request free samples at ibidi.com.

ibidi

For info: 844-276-636 3

ibidi.com

Automated Cell Culture Analyzer

BioProfile FLEX2 combines Nova’s groundbreaking MicroSensor

Card technology with optical measurement and freezing point

osmometry for an automated, comprehensive cell culture analyzer

that eliminates chemistry sensor maintenance, increases analyzer

speed, and reduces sample volume. The full 16-cell-culture test

menu includes glucose, lactate, glutamine, glutamate, ammonium,

sodium, potassium, calcium, pH, PCO 2 , PO 2 , total cell density, viable

cell density, viability, cell diameter, and osmolality. Compared to the

previous generation BioProfile FLEX, there is no maintenance for any

of the 11 chemistry and gas sensors, sample volume for the full test

menu is reduced by 75% to 275 μL, and testing time is reduced to

just 4.5 min. Automated sampling from 96-well plates, syringes, or a

24-position external “load-and-go” sample tray provides maximum

workflow flexibility and efficiency for cell culture monitoring.

Nova Biomedical

For info: 781-894-0800

http://www.novabio.us/flex-2/index.php

Inductive Charging Stand

An inductive charging stand is now available for the BRAND

HandyStep touch and HandyStep touch S repeating pipettes. The

stand allows for easy charging of the instrument without a plug

connection. A blue light indicates when the instrument is charging

and goes out when charging is completed. A tip can be inserted,

and the instrument can be used simultaneously while charging. The

stand is available separately or in an attractively priced bundle with

either pipette.

BrandTech Scientific

For info: 888-522-2726

http://www.brandtech.com