Article
Extended Data Fig. 2 | Interface between SARS-CoV-2 or SARS-CoV RBM and
ACE2. a, The interface between the SARS-CoV RBD and ACE2, showing a strong
salt bridge between Arg426 on the side loop of the RBM and Glu329 of ACE2.
The core structure is shown in grey. The RBM is shown in orange. b, The
interface between the SARS-CoV-2 chimeric RBD and ACE2, showing a weaker,
but still energetically favourable, NāO bridge between Arg439 on the side loop
of the RBM and Glu329 of ACE2. The interaction between Arg439 on the side
loop of the RBM and Glu329 of ACE2 is non-natural in SARS-CoV-2 (and is a result
of the design of the SARS-CoV-based chimaera).