wrote the manuscript.Competing interests:The Hospital for
Sick Children receives royaltiesfrom Trillium Therapeutics, Inc.
for SIRPa-Fc, of which J.S.D. receives a fraction. J.S.D. is a
coinventor on a patent related to this work,“Role of SIRP alpha
polymorphisms in human acute myeloid leukemia.”PCT
applications are pending in the United States, Canada, and
China and have been awarded in Australia (2015) and Japan
(2018).Data and materials availability:Raw scRNA-seq data
have been deposited into the Gene Expression Omnibus (GEO)
database (accession no. GSE147596). All other data needed to
evaluate the conclusions of the paper are available in the
manuscript or the supplementary materials.
SUPPLEMENTARY MATERIALS
science.sciencemag.org/content/368/6495/1122/suppl/DC1
Materials and Methods
Figs. S1 to S5
Tables S1 to S4References ( 20 – 28 )
Data S1 and S2View/request a protocol for this paper fromBio-protocol.20 March 2019; resubmitted 2 December 2019
Accepted 10 April 2020
Published online 7 May 2020
10.1126/science.aax4040Daiet al.,Science 368 , 1122–1127 (2020) 5 June 2020 6of6
RESEARCH | REPORT