Science - USA (2020-06-05)

experiments. S.A.B. purifiedCas13 proteins. R.C.B.-O. and
F.H.R.-G. designed and constructedB. subtilisstrains and purified
spores (supervised by D.Z.R.). D.Z.R., P.A.S., A.S.K., and M.B.
provided critical insights. All authors reviewed the manuscript.
Competing interests:U.S. provisional patent application no. US
62/958,512 has been filed on behalf of M.S. and the President
and Fellows of Harvard College.Data and materials

availability:All data are available in the article or the

supplementary materials.

SUPPLEMENTARY MATERIALS

science.sciencemag.org/content/368/6495/1135/suppl/DC1

Materials and Methods

Supplementary Text

Figs. S1 to S19

Tables S1 to S6

View/request a protocol for this paper fromBio-protocol.

13 December 2019; accepted 31 March 2020

10.1126/science.aba5584

Qianet al.,Science 368 , 1135–1140 (2020) 5 June 2020 6of6

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