Article
Extended Data Fig. 12 | Reconstruction of the nigrostriatal pathway by
converted dopaminergic neurons. a, Schematic of the experimental
schedule for 6-OHDA-induced lesion and reconstruction of the nigrostriatal
pathway. b–f, Images of RFP+ projections extending from substantia nigra to
striatum. The schematic diagram shows the dorso-ventral level of the
horizontal section. Scale bar, 100 μm. Magnified views show indicated brain
regions (c–f). Scale bar, 25 μm. g, Amplified views of RFP-positive fibres that
co-stained with TH in CPu and globus pallidus. Scale bar, 20 μm. These data
were used to provide the quantitative information shown in Fig. 4h, i.
Experiments were independently repeated twice with similar results.