n=11
2
3
3
3
3
11
12
11 11 7
4
7
4
4
4
4
3
4
4
4
Leukocytes
in PBMCs
NK
pDC
mDC
B
Mono
T
AE
AE/ID
IV
ID
low
ID
high
P 2 4 8 12 16 20 24
AE
AE/ID
IV
ID
low
ID
high
P 2 4 8 12 16 20 24
Weeks after BCG immunization
P 2 4 24
AE
IV
ID
high
ID
low
Weeks after BCG
NK
Neut
pDC
mDC
B
MΦ
T
Leukocytes in BAL
T cells in BAL
CD4
CD8
MAIT
iNKT
Vγ 9 +
T cells
in PBMCs
CD4
CD8
V 9 +
MAIT
iNKT
V 9 –
P 2 4 24
AE
IV
ID
high
ID
low
Weeks after BCG
Weeks after BCG immunization
a
b
c d
0.047
0.012
<0.001 <0.001 <0.001 <0.001 <0.001 0.003 <0.001
0.003 <0.001 0.029
0.032 <0.001 0.016 0.020 0.036
0.039
0.015
0.002 0.009 0.003 <0.001 0.021
Extended Data Fig. 3 | See next page for caption.