a
b
Total IL-17 (%)
Pie colors
IFN
IL-2
TNF
IFN
IL-2
TNF
CD154
IFN
IL-2
TNF
IFN
IL-2
TNF
CD4 Response (PBMCs)
CD8 Response (PBMCs)
CD4 Response (BAL)
CD8 Response (BAL)
Cytokine-producing
T cells in PBMCs (%)
Cytokine-producing
T cells in BA
L (%)
IL-17 positive (total)
IL-17 single-positive
Pie colors
Pie colors
Pie colors
2.0
3.0
1.0
0.0
0.0
0.4
0.8
0
10
20
30
0
4.0
8.0
12.0
0.0
0.4
0.8
0
4
8
0.0
0.1
0.2
To tal IL-17 (%)
To tal IL-17 (%)
IDlow IDhigh IV AE AE/ID
IDlow IDhigh IV AE AE/ID
IDlow IDhigh IV AE AE/ID
IDhigh IV
IL-17 positive (total)
IL-17 single-positive
Bars
AE
AE/ID
IV
IDlow
IDhigh
CD154 single-positive
Extended Data Fig. 5 | See next page for caption.