a
b
c
d
BCG Regimen
048 12 048 12 04812 048 12 048 12
0
1
2
4
8
0.0
0.5
1.0
1.5
2
0.0
0.5
1.0
1.5
4
8
048 12
tntc
400
300
200
100
10
0
tntc
400
300
200
100
10
0
0 4 6 812 0 4 6 812 0 4 6 812 0 4 6 8120 4 6 812 0 4 6 812
0
1
2
3
4
8
Weeks after Mtb challenge
Weeks after Mtb challenge
048 12 048 12 048 12 04812 048 12 048 12
IFN
spot-forming units (per 200,000 cells)
Cytokine-producing CD4
T cells (%)
Cytokine-producing CD8
T cells (%)
ESAT-6 (Mtb only)
CFP-10 (Mtb only)
PPD (BCG/Mtb)
ES
AT
-6/CFP-10
PPD (BCG/Mtb)
ES
AT
-6/CFP-10
log
10
(endpoint titer)
IgG
IgA
IgM
0 4 12
2
3
4
5
6
1
2
3
4
5
1
2
3
4
5
Unvax IDlow IDhigh IV AE AE/ID
Unvax IDlow IDhigh IV AE AE/ID
Weeks after Mtb
0.00 2
0.00 4
0.00 2
0.00 6
0.00 2
0.00 4
0.004
0.004 0.016 0.695 0.004 0.006
0.002 0.008 0.160 0.004 0.002
0.004 0.008 0.625 0.00 20 .002
0.004 0.039 0.031 0.014 0.006
IDhigh
IV
AE
IDlow
AE/ID
Unvax
log
10
(endpoint titer)
log
10
(midpoint titer)
Extended Data Fig. 9 | See next page for caption.