IFN
ivCD45
0
1
2
3
4
5
PBMC
Bone marrow
Spleen
Liver
Skin
Axillary LNInguinal LNMesenteric LN
Hilar LNCarinal LN
BALRU
LR LRLR LR
RMRLLULMAcc
Lung
lobes
0
1
2
3
4
5
PBMC
Bone marrow
Spleen
Liver
Axillary LNInguinal LNMesenteric LN
Hilar LNCarinal LN
BALRU
LRLR LR
RMRLLULMAcc
Lung
lobes
0
1
2
3
4
5
PBMC
Bone marrow
Spleen
Liver
Axillary LNInguinal LNMesenteric LN
Hilar LN
BALRU
LRLR R
RMRLLULMAcc
Lung
lobes
0
1
2
3
4
5
PBMC
Bone marrow
Spleen
Liver
Axillary LNInguinal LNMesenteric LN
Hilar LNCarinal LN
BALRU
LRLR LR
RMRLLULMAcc
Lung
lobes
Pre-infusion Systemic
PBMCPost-infusionPBMC B. marrow Spleen
L. axillary R. axillary L. inguinal R. inguinal Mesenteric
L. hilar R. hilar Carinal
BAL R. upper R. middle R. lowerL. upperL. lower Accessory
Peripheral
LN
LNLung
BAL &
lung lobes
IDhigh
log
(BCG CFU) 10
IV
AE
EB
a
Pre-infusion Systemic
PBMCPost-infusionPBMC B. marrow Spleen
L. axillary R. axillary L. inguinal R. inguinalMesenteric
L. hilar R. hilar Carinal
BAL R. upper R. middle R. lowerL. upper L. lower
Peripheral
LN
BAL &
lung lobes
Pre-infusion Systemic
PBMC
Post-infusion
PBMC
B. marrow Spleen
L. axillary R. axillary L. inguinal R. inguinal Mesenteric
L. hilar
BAL R. upper R. middle R. lowerL. upperL. lower
Peripheral
LN
Accessory BA
L &
lung lobes
Pre-infusion Systemic
PBMC
Post-infusion
PBMC
B. marrow Spleen
L. axillary R. axillary L. inguinal R. inguinalMesenteric
L. hilar R. hilar Carinal
BAL R. upper R. middle R. lowerL. upper L. lower
Peripheral
LN
Accessory lung lobesBAL &
LNLung
LNLung
IFN
IFN
N
FN
FN
b
c
d
log
(BCG CFU) 10
log
(BCG CFU) 10
log
(BCG CFU) 10
Extended Data Fig. 12 | See next page for caption.