SCIENCE sciencemag.org 15 FEBRUARY 2019 • VOL 363 ISSUE 6428 669CONTENTS699
SCIENCE (ISSN 0036-8075) is published weekly on Friday, except last week in December, by the American Association for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005. Periodicals mail
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(CCC), http://www.copyright.com. The identification code for Science is 0036-8075. Science is indexed in the Reader’s Guide to Periodical Literature and in several specialized indexes.RESEARCH
IN BRIEF
703 From Science and other journalsREVIEW
706 MAGNETISM
Two-dimensional magnetic crystals and
emergent heterostructure devices
C. Gong and X. Zhang
REVIEW SUMMARY; FOR FULL TEXT:
dx.doi.org/1 0. 1126 /science.aav 4450RESEARCH ARTICLES
707 NEURODEGENERATION
Heterochromatin anomalies and double-
stranded RNA accumulation underlie
C9orf72 poly(PR) toxicity
Y.- J. Z h a n g et al.
RESEARCH ARTICLE SUMMARY; FOR FULL TEXT:
dx.doi.org/ 10. 1126 /science.aav 2606708 STRUCTURAL BIOLOGY
Recognition of the amyloid precursor
protein by human g-secretase
R. Zhou et al.
RESEARCH ARTICLE SUMMARY; FOR FULL TEXT:
dx.doi.org/ 10 .1 126 /science.aaw0 930
▶ PERSPECTIVE P. 690709 TOXINS
The human gut bacterial genotoxin
colibactin alkylates DNA
M. R. Wilson et al.
RESEARCH ARTICLE SUMMARY; FOR FULL TEXT:
dx.doi.org/ 10. 1126 /science.aar 7785
▶ PERSPECTIVE P. 689710 STRUCTURAL BIOLOGY
A human postcatalytic spliceosome
structure reveals essential roles of
metazoan factors for exon ligation
S. M. Fica et al.REPORTS
715 SURFACE SCIENCE
Density fluctuations as door-opener for
diffusion on crowded surfaces
A.-K. Henß et al.
▶ PERSPECTIVE P. 695719 DEVICE TECHNOLOGY
Printed subthreshold organic transistors
operating at high gain and ultralow
power C. Jiang et al.723 CERAMICS
Double-negative-index ceramic
aerogels for thermal superinsulation
X. Xu et al.
▶ PERSPECTIVE P. 694728 QUANTUM OPTICS
Photoelectrical imaging and
coherent spin-state readout of
single nitrogen-vacancy centers
in diamond P. Siyushev et al.731 NANOMATERIALS
Chemically reversible
isomerization of inorganic clusters
C. B. Williamson et al.736 GEOPHYSICS
Inferring Earth’s discontinuous
chemical layering from the
660-kilometer boundary topography
W. Wu et al.
▶ PERSPECTIVE P. 696740 STRUCTURAL BIOLOGY
How a circularized tmRNA moves
through the ribosome C. D. Rae et al.744 STRUCTURAL BIOLOGY
Structural insight into nucleosome
transcription by RNA polymerase II
with elongation factors
H. Ehara et al.748 IMMUNOLOGY
BCR-dependent lineage plasticity
in mature B cells R. Graf et al.753 STRUCTURAL BIOLOGY
Structural insight into substrate
and inhibitor discrimination
by human P-glycoprotein
A. Alam et al.PHOTO: MARION KAPLAN/ALAMY STOCK PHOTO
ON THE COVER
In winter, snow-
shoe hares (Lepus
americanus) molt from
brown to white coats
to maintain camouflage
in snow-covered
environments. This
seasonal adaptation
has evolved in several
animal species and can result in camouflage
mismatch as snow duration decreases. The
Gordon Research Conference on Ecological
and Evolutionary Genomics will be held
from 14 to 19 July 2019 in Manchester,
New Hampshire. See page 758 for the
Gordon Research Conference schedule and
preliminary programs. Photo: Colin RuggieroDEPARTMENTS
671 EDITORIAL
Keep science on the horizon
By Sir John Beddington786 WORKING LIFE
Waiting for reimbursement
By Jessica SagersScience Staff ..............................................
Gordon Research Conferences .................
New Products .............................................
Science Careers .........................................698 ROY GLAUBER (1925–2018)
Father of quantum optics
By M. O. Scully and S. PrasadBOOKS ET AL.
699 CONSERVATION AND CONFLICT
Afghanistan’s rich natural heritage
shines in an insider’s account of the
foundings of its first national parks
By R. Cooney and K. Karimov700 OVERLOOKED NO LONGER
A new play honors the enslaved black
women who helped improve our
understanding of reproductive health
By D. Cooper OwensLETTERS
701 SAVING CHINA’S ONAGER
By Y. Li et al.701 HEMP HEMP HOORAY FOR CANNABIS
RESEARCH
By C. Schluttenhofer and L. Yuan702 ARGENTINA’S SUBPAR INVESTMENT
IN SCIENCE
By H. A. Carignano and J. P. JaworskiPublished by AAASon February 18, 2019^http://science.sciencemag.org/Downloaded from