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ACKNOWLEDGMENTS
We thank T. Sumida from Yale University for sharing RNA-seq data
and J. He from Yan Wang’s laboratory for his help with
immunofluorescent staining.Funding:The study was supported by
the National Key Research and Development Program of China
(2016YFA0101200 to X.L. and X.-W.B.) and the National Natural
Science Foundation of China (31770973 to X.L., 81703531 to
X.W., and 81101982 to Z.Y.)Author contributions:
Conceptualization: X.L.; Investigation: X.W., Yu.W., R.H., Q.G., M.S.,
Ha.L., Xiaow.Y., Xiang Z., Y.S., S.X., Lo.C., Xia Z., Z.Y., F.W.,
Hu.L., and Xiaoh.Y.; Mouse strain provider: B.Z., F.W., Li.C., and
C.D.; Supervision: X.L., X.-W.B., and Ya.W.Competing interests:
The authors declare no competing interests.Data and materials
availability:RNA-seq, scRNA-seq, and ATAC-seq (assay for
transposase-accessible chromatin using sequencing) data have
been deposited in the Gene Expression Omnibus (GSE142523).SUPPLEMENTARY MATERIALS
science.sciencemag.org/content/369/6506/984/suppl/DC1
Materials and Methods
Figs. S1 to S15
References ( 28 – 35 )
View/request a protocol for this paper fromBio-protocol.20 December 2019; accepted 12 June 2020
10.1126/science.aba6652Wuet al.,Science 369 , 984–988 (2020) 21 August 2020 5of5
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