Extended Data Fig. 3 | Normalized CpG distributions for tuatara and other
vertebrates. Tuatara show a statistically significant bimodal normalized CpG
distribution in all genomic regions examined (gene promoters, exons, introns
and intergenic sequences). Explicit testing using mixed models uncovered
global normalized CpG bimodality across all taxa, indicating that bimodality is
ancestral and highly conserved across vertebrates irrespective of
sex-determining mechanism. Further details are provided in Supplementary
Information 8. Silhouettes are hand-drawn from the original photographs of
A. Eckley, except for Anolis (D. Hobern, CC-BY-2.0), crocodile and hen (designed
by Creazilla, https://creazilla.com/).