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Extended Data Fig. 8 | Analysis of antibody somatic hypermutation and
CDR3 length. a, For each individual, the number of somatic nucleotide
mutations at the IGVH and IGVL is shown on the left, and the amino acid length
of the CDR3s is shown on the right. The horizontal bars indicate the mean. The
number of antibody sequences (IGVH and IGVL) evaluated for each participant
are n = 118 (COV107), n = 127 (COV21), n = 79 (COV47), n = 54 (COV57), n = 78
(COV 72), n = 78 (COV96). b, Same as in a but for all antibodies combined (n = 53 4
for both IGVH and IGVL). c, Distribution of the hydrophobicity GR AV Y scores at
the IGH CDR3 in antibody sequences from this study compared to a public
database (see Methods for statistical analysis). The box limits are at the lower
and upper quartiles, the centre line indicates the median, the whiskers are 1.5×
interquartile range and the dots represent outliers.