Nature - USA (2020-08-20)

(Antfer) #1

Article


01234

0

25

50

75

100

Log 10 [m Ab](ng/m l)

%R

elativeIn fe c tion

COV2-2813
COV2-2819
COV2-2828
COV2-2832
COV2-2835
COV2-2841
COV2-2919
COV2-2165
COV2-2955
COV2-2098

1234
Log 10 [mAb](ng/ml)

%

Re

la tive

Infe

c t io

n

COV2-2354
COV2-2072
COV2-2381
COV2-2096
COV2-2489
COV2-2499
COV2-2050
COV2-2094
COV2-2539
0 COV2-2562

25

50

75

100

1234
Log 10 [mAb] (ng/ml)

% Relative

Infectio

n

COV2-3 025
COV2-2 103
COV2-2 113
COV2-2 807
COV2-2 812
COV2-2 015
COV2-2 258
COV2-2 268
COV2-2 308

(^0) COV2-2 353
25
50
75
100
01234
Log 10 mAb
%R
elat
iv eI
nf
ect
ion
COV2-256 2
COV2-267 6
COV2-267 7
COV2-208 2
COV2-273 3
COV2-275 2
COV2-278 0
COV2-206 8
COV2-219 6
COV2-247 9
0 COV2-^2130
25
50
75
100
mAb concentration (log 10 ng/mL)
% SARS-CoV-2 neutralization
Extended Data Fig. 1 | SARS-CoV-2 neutralization curves for monoclonal antibody panel. Neutralization of wild-type SARS-CoV-2 by human monoclonal
antibodies. Data are mean ± s.d. of technical duplicates, and represent one of two or more independent experiments.

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