(^0) -1 01234
25
50
75
100
mAbconcentration (ng/mL)
O.D. 450 nm
(^0) -1 0123 4
25
50
75
100
mAbconcentration (ng/mL)
O.D.450 nm
(^0) -1 0 1234
25
50
75
100
mAbconcentration (ng/mL)
O.D.450 nm
(^0) -1 0 123 4
25
50
75
100
mAbconcentration (ng/mL)
O.D. 450n m
(^0) -1 0 1234
25
50
75
100
mAbconcentration (ng/mL)
O.D. 450nm
(^0) -1 0 123 4
25
50
75
100
mAbconcentration (ng/mL)
O.D.450n m
(^0) -1 0 123 4
25
50
75
100
mAbconcentration (ng/mL)
O.D. 450nm
(^0) -1 0123 4
25
50
75
100
mAbconcentration (ng/mL)
O.D.450nm
(^0) -1 0123 4
25
50
75
100
mAbconcentration (ng/mL)
O.D.450 nm
(^0) -1 0123 4
25
50
75
100
mAbconcentration (ng/mL)
O.D. 450nm
(^0) -1 0 123 4
25
50
75
100
mAbconcentration (ng/mL)
O.D. 450 nm
(^0) -1 0 123 4
25
50
75
100
mAbconcentration (ng/mL)
O.D. 450nm
(^0) -1 0123 4
25
50
75
100
mAbconcentration (ng/mL)
O.D. 450n m
(^0) -1 01234
25
50
75
100
mAbconcentration (ng/mL)
O.D. 450nm
(^0) -1 0 123 4
25
50
75
100
mAbconcentration (ng/mL)
O.D. 450n m
(^0) -1 0123 4
25
50
75
100
mAbconcentration (ng/mL)
O.D. 450n m
(^0) -1 0 123 4
25
50
75
100
mAbconcentration (ng/mL)
O.D. 450 nm
(^0) -1 0 123 4
25
50
75
100
mAbconcentration (ng/mL)
O.D. 450nm
(^0) -1 0123 4
25
50
75
100
mAbconcentration (ng/mL)
O.D. 450n m
(^0) -1 0 1234
25
50
75
100
mAbconcentration (ng/mL)
O.D. 450 nm
(^0) -1 0 123 4
25
50
75
100
mAbconcentration (ng/mL)
O.D. 450n m
(^0) -1 0 1234
25
50
75
100
mAbconcentration (ng/mL)
O.D.450nm
(^0) -1 0 123 4
25
50
75
100
mAbconcentration (ng/mL)
O.D. 450 nm
(^0) -1 01234
25
50
75
100
mAbconcentration (ng/mL)
O.D. 450 nm
(^0) -1 0123 4
25
50
75
100
mAbconcentration (ng/mL)
O.D.450 nm
(^0) -1 0 1234
25
50
75
100
mAbconcentration (ng/mL)
O.D.450 nm
(^0) -1 0 123 4
25
50
75
100
mAbconcentration (ng/mL)
O.D. 450n m
(^0) -1 0 1234
25
50
75
100
mAbconcentration (ng/mL)
O.D. 450nm
(^0) -1 0 123 4
25
50
75
100
mAbconcentration (ng/mL)
O.D.450n m
(^0) -1 01234
25
50
75
100
mAbconcentration (ng/mL)
O.D. 450 nm
(^0) -1 0123 4
25
50
75
100
mAbconcentration (ng/mL)
O.D.450 nm
(^0) -1 0 1234
25
50
75
100
mAbconcentration (ng/mL)
O.D.450 nm
(^0) -1 0 123 4
25
50
75
100
mAbconcentration (ng/mL)
O.D. 450 nm
(^0) -1 0 1234
25
50
75
100
mAbconcentration (ng/mL)
O.D. 450nm
(^0) -1 0 123 4
25
50
75
100
mAbconcentration (ng/mL)
O.D.450 nm
(^0) -1 01234
25
50
75
100
mAbconcentration (ng/mL)
O.D. 450 nm
(^0) -1 0123 4
25
50
75
100
mAbconcentration (ng/mL)
O.D.450 nm
(^0) -1 0 1234
25
50
75
100
mAbconcentration (ng/mL)
O.D.450 nm
(^0) -1 0 123 4
25
50
75
100
mAbconcentration (ng/mL)
O.D. 450n m
(^0) -1 0 1234
25
50
75
100
mAbconcentration (ng/mL)
O.D. 450nm
(^0) -1 0 123 4
25
50
75
100
mAbconcentration(ng/mL)
O.D. 450n
m
(^0) -1 01234
25
50
75
100
mAbconcentration(ng/mL)
O. D.450nm
COV2-2015 COV2-2050 COV2-2068 COV2-2072 COV2-2082 COV2-2094
COV2-2096 COV2-2098 COV2-2103 COV2-21 13 COV2-2130 COV2-2165
COV2-2196 COV2-2258 COV2-2268 COV2-2308 COV2-2353 COV2-2354
COV2-2381 COV2-2479 COV2-2489 COV2-2499 COV2-2539 COV2-2562
COV2-2676 COV2-2677 COV2-2733 COV2-2752 COV2-2780 COV2-2807
COV2-2812 COV2-2813 COV2-2819 COV2-2828 COV2-2832 COV2-2835
COV2-2841 COV2-2919 COV2-2955 COV2-3025 rCR3022 r2D22
mAb concentration (log 10 ng/mL)
% human
ACE2 binding inhibition
Extended Data Fig. 2 | Inhibition curves for monoclonal antibody
inhibition of S2Pecto binding to human ACE2. Blocking of human ACE2
binding to S2Pecto by anti-SARS-CoV-2 neutralizing human monoclonal
antibodies. Data are mean ± s.d. of triplicates of one experiment. Antibodies
rCR3022 and r2D22 served as controls.
antfer
(Antfer)
#1