Extended Data Fig. 6 | Sequence features of the human monoclonal
antibodies used in animal studies and monoclonal antibody
pharmacokinetics following their administration to NHPs. a, Sequence
features of human monoclonal antibodies tested in animal models. Inferred
variable genes are indicated and CDR3 amino acids are shown for heavy and
light chains. b, Macaques received one 50 mg kg−1 dose of COV2-2196, COV2-
2381 or an isotype control monoclonal antibody (n = 4 macaques per group)
intravenously on day −3 and then were challenged intranasally and
intratracheally with SARS-CoV-2 at day 0. The concentration of human
monoclonal antibodies was determined at indicated time points. Each curve
shows an individual macaque. Data represent a single experiment.