Science - USA (2020-09-04)

CREDITS: (LEFT) V. ALTOUNIAN/

SCIENCE,

(PROTEIN STRUCTURE DATA) W. SONG

ET AL

. PLOS PATHOGENS

10.1371/JOURNAL.PPAT.1007236 (2018) AND R. YAN

ET AL

. SCIENCE

367

, 1444 (2020); (RIGHT) ROBERT NEUBECKER

SCIENCE sciencemag.org 4 SEPTEMBER 2020 • VOL 369 ISSUE 6508 1145

1227 Protein design

A defined structural unit enables de novo

design of small-molecule–binding proteins

N. F. Polizzi and W. F. DeGrado

PERSPECTIVE p. 1166

REPORTS

1233 Stellar astrophysics

A triple-star system with a misaligned

and warped circumstellar disk

shaped by disk tearing S. Kraus et al.

1238 Metrology

Proton-electron mass ratio from laser

spectroscopy of HD+ at the part-per-trillion

level S. Patra et al.

PERSPECTIVE p. 1160

1242 Climate responses

Predicting temperature mortality and

selection in natural Drosophila populations

E. L. Rezende et al.

PERSPECTIVE p. 1163

1245 Biogeochemistry

Plants sustain the terrestrial silicon

cycle during ecosystem retrogression

F. de Tombeur et al.

PERSPECTIVE p. 1161

1249 Coronavirus

Structural basis for translational

shutdown and immune evasion

by the Nsp1 protein of SARS-CoV-

M. Thoms et al.

1255 Coronavirus

Evolution and epidemic spread

of SARS-CoV-2 in Brazil

D. S. Candido et al.

1261 Coronavirus

Engineering human ACE

to optimize binding to the spike

protein of SARS coronavirus 2

K. K. Chan et al.

PERSPECTIVE p. 1167

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CONTENTS

DEPARTMENTS

1146 Editorial

Reopening schools during COVID-

By Ronan Lordan et al.

1147 Editorial

Enshrining equity in democracy

By Evelynn M. Hammonds

DEMOCRACY IN THE BALANCE SECTION p. 1174

1270 Working Life

Mentoring with trust

By René S. Shahmohamadloo

New Products ........................................... 1266

Science Careers ....................................... 1267

RESEARCH

IN BRIEF

1203 From Science and other journals

RESEARCH ARTICLES

1206 Cell biology

Reconstitution of autophagosome

nucleation defines Atg9 vesicles

as seeds for membrane formation

J. Sawa-Makarska et al.

RESEARCH ARTICLE SUMMARY; FOR FULL TEXT:

DX.DOI.ORG/10.1126/SCIENCE.AAZ

1207 Regeneration

Changes in regeneration-responsive

enhancers shape regenerative

capacities in vertebrates

W. Wa n g et al.

RESEARCH ARTICLE SUMMARY; FOR FULL TEXT:

DX.DOI.ORG/10.1126/SCIENCE.AAZ

1208 Neuroscience

Regulation of sleep homeostasis mediator

adenosine by basal forebrain glutamatergic

neurons W. Pe n g et al.

RESEARCH ARTICLE SUMMARY; FOR FULL TEXT:

DX.DOI.ORG/10.1126/SCIENCE.ABB

Coronavirus

1209 Deep immune profiling of COVID-

patients reveals distinct immunotypes

with therapeutic implications

D. Mathew et al.

RESEARCH ARTICLE SUMMARY;

FOR FULL TEXT: DX.DOI.ORG/

10.1126/SCIENCE.ABC

1210 Systems biological assessment of

immunity to mild versus severe

COVID-19 infection in humans

P. S. Arunachalam et al.

SCIENCE IMMUNOLOGY RESEARCH ARTICLE

BY L. KURI-CERVANTES ET AL.

10.1126/SCIIMMUNOL.ABD

1220 Structural biology

Structure of a human 48S translational

initiation complex J. Brito Querido et al.

1171 Support transgender scientists

post–COVID-

By S. Turney et al.

1172 Adapt taxonomy to

conservation goals

By D. P. O’Connell et al.

1167 &

1261

1270

Published by AAAS