Article
Extended Data Fig. 10 | Working model of simultaneous consolidation and
storage of threat and safety cue-associated memories in CeL SOM and
PKCδ INs, respectively. In a differential threat conditioning paradigm, cued
threat mobilizes the translation machinery in CeL SOM INs via activation of
Gq-coupled GPCR(s), and the ensuing de novo protein synthesis in these
neurons is necessary for long-term storage of a cued threat response. The cued
safety signal, on the other hand, is processed by CeL PKCδ INs with engagement
of the cell-autonomous protein synthesis machinery, leading to long-term
storage of the cued safety response.